Publication Highlights

  • dos Santos E, Xie Y, Cao E, Foley A, Taylor ME, Andrew I, Young G, Trevaskis NL & Cochemé HM (2024) “Systemic extracellular acidification is a hallmark of aging”. BioRxiv 2024.09.24.614672. LINK
  • dos Santos E & Cochemé HM (2024) “Pharmacology of Aging: Drosophila as a tool to validate drug targets for healthy lifespan” Aging Biol 2:20240034. LINK
  • dos Santos E & Cochemé HM (2024) “How does a fly die? Insights into ageing from the pathophysiology of Drosophila mortality” GeroScience 46:4003-4015. LINK
  • Lennicke C & Cochemé HM (2021) “Redox metabolism: ROS as specific molecular regulators of cell signaling and function” Mol Cell 81:3691-3707. LINK
  • Lennicke C & Cochemé HM (2021) “Redox regulation of the insulin signalling pathway” Redox Biol 42:101964. LINK
  • van Dam E, van Leeuwen LAG, Dos Santos E, James J, Best L, Lennicke C, Vincent AJ, Marinos G, Foley A, Buricova M, Mokochinski JB, Kramer HB, Lieb W, Laudes M, Franke A, Kaleta C, Cochemé HM (2020) “Sugar-Induced Obesity and Insulin Resistance Are Uncoupled from Shortened Survival in Drosophila” Cell Metab 31:710-725. LINK
  • Lennicke C & Cochemé HM (2020) “Redox signalling and ageing: insights from Drosophila” Biochem Soc Trans  48:367-377. LINK
  • Pryor R, Norvaisas P, Marinos G, Best L, Thingholm LB, Quintaneiro LM, De Haes W, Esser D, Waschina S, Lujan C, Smith RL, Scott TA, Martinez-Martinez D, Woodward O, Bryson K, Laudes M, Lieb W, Houtkooper RH, Franke A, Temmerman L, Bjedov I, Cochemé HM, Kaleta C & Cabreiro F (2019) “Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy” Cell 178:1299-1312. LINK​
  • Cochemé HM, Logan A, Prime TA, Abakumova I, Quin C., McQuaker SJ, Patel JV, Fearnley IM, James AM, Porteous CM, Smith RAJ, Hartley RC, Partridge L & Murphy MP (2012) “Using the mitochondria-targeted ratiometric mass spectrometry probe MitoB to measure H2O2 within living Drosophila” Nat Protoc 7:946-958. LINK
  • Collins Y, Chouchani ET, James AM, Menger KE, Cochemé HM & Murphy MP (2012) “Mitochondrial redox signalling at a glance” J Cell Sci 15:801-806. LINK
  • Smith RAJ, Hartley RC, Cochemé HM & Murphy MP (2012) “Mitochondrial Pharmacology” Trends Pharm Sci 33(6):341-352. LINK
  • Cochemé HM, Quin C, McQuaker SJ, Cabreiro F, Logan A, Prime TA, Abakumova I, Patel JV, Fearnley IM, James AM, Porteous CM, Smith RAJ, Saeed S, Carré JE, Singer M, Gems D, Hartley RC, Partridge L & Murphy MP (2011) “Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix” Cell Metab 13:340-350. LINK
  • Cochemé HM & Murphy MP (2010) “Can antioxidants be effective therapeutics?” Curr Opin Investig Drugs 11:426-431. LINK
  • Cochemé HM & Murphy MP (2008) “Complex I is the major site of mitochondrial superoxide production by paraquat” J Biol Chem 283:1786-1798. LINK

Full Publications List
Google Scholar Citations
2024
  • dos Santos E, Xie Y, Cao E, Foley A, Taylor ME, Andrew I, Young G, Trevaskis NL & Cochemé HM (2024) “Systemic extracellular acidification is a hallmark of aging”. BioRxiv 2024.09.24.614672. LINK
  • dos Santos E & Cochemé HM (2024) “Pharmacology of Aging: Drosophila as a tool to validate drug targets for healthy lifespan” Aging Biol 2:20240034. LINK
  • Cochemé HM & Gil J (2024) “mTOR links nutrients, inflammaging and lifespan” Nat Aging 4:1034-1035. LINK
  • dos Santos E & Cochemé HM (2024) “How does a fly die? Insights into ageing from the pathophysiology of Drosophila mortality” GeroScience 46:4003-4015. LINK
  • Martinez-Martinez D, Peres TV, Gehling K, Quintaneiro L, Cabrera C, Cutty SJ, Best L, Marinos G, Zimmerman J, Safoor A, Chrysostomou D, Mokochinsky JB, Montoya A, Zatorska M, Scott T, Andrew I, Kramer H, Begum M, Zhang B, Golding BT, Marchesi JR, Hirabayashi S, Kaleta C, Barr AR, Frezza C, Cochemé HM & Cabreiro F (2024) “Chemotherapy Modulation by a Cancer-Associated Microbiota Metabolite” Sneak Peek Pre-Print. LINK
2021
  • Lennicke C & Cochemé HM (2021) “Redox metabolism: ROS as specific molecular regulators of cell signaling and function” Mol Cell 81:3691-3707. LINK
  • Lennicke C & Cochemé HM (2021) “Redox regulation of the insulin signalling pathway” Redox Biol 42:101964. LINK
2020
  • Lennicke C & Dos Santos E, Cochemé HM (2020) “Sugar-induced dysregulation of purine metabolism impacts lifespan” Aging 12:24479-24480. LINK
  • Bjedov I, Cochemé HM, Foley A, Wieser D, Castillo-Quan JI, Woodling NS, Norvaisas P, Lujan C, Regan JC, Toivonen JM, Murphy MP, Thornton J, Kinghorn K, Neufeld T, Cabreiro F & Partridge L. (2020) Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression (2020) PLOS Genet 16:e1009083. LINK
  • van Dam E, van Leeuwen LAG, Dos Santos E, James J, Best L, Lennicke C, Vincent AJ, Marinos G, Foley A, Buricova M, Mokochinski JB, Kramer HB, Lieb W, Laudes M, Franke A, Kaleta C & Cochemé HM (2020) “Sugar-Induced Obesity and Insulin Resistance Are Uncoupled from Shortened Survival in Drosophila” Cell Metab 31:710-725. LINK
  • Lennicke C & Cochemé HM (2020) “Redox signalling and ageing: insights from Drosophila” Biochem Soc Trans  48:367-377. LINK
2019
  • Cochemé HM*, Bjedov I, Grönke S, Menger KE, James AM, Castillo-Quan JI, Foley A, Lennicke C, Buricova M, Adcott J, Cabreiro F, Murphy MP, Partridge L* (2019) "Enhancing autophagy by redox regulation extends lifespan in Drosophila" BioRxiv 790378. *co-corresponding author LINK
  • Pryor R, Norvaisas P, Marinos G, Best L, Thingholm LB, Quintaneiro LM, De Haes W, Esser D, Waschina S, Lujan C, Smith RL, Scott TA, Martinez-Martinez D, Woodward O, Bryson K, Laudes M, Lieb W, Houtkooper RH, Franke A, Temmerman L, Bjedov I, Cochemé HM, Kaleta C & Cabreiro F (2019) “Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy” Cell 178:1299-1312. LINK
2017
  • van Leeuwen LAG, Hinchy EC, Murphy MP, Robb EL & Cochemé HM (2017) “Click-PEGylation - A mobility shift approach to assess the redox state of cysteines in candidate proteins” Free Radic Biol Med 108:374-382. LINK
  • Kerr F, Sofola-Adesakin O,Ivanov DK, Gatliff J, Perez-Nievas BG, Bertrand HC, Martinez P, Callard R, Snoeren I, Cochemé HM, Adcott J, Khericha M, Castillo-Quan JI, Wells G, Noble W, Thornton J & Partridge L (2017) “Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s disease” PLOS Genet 13:e1006593. LINK
  • Augustin H, McGourty K, Steinert JR, Cochemé HM, Adcott J, Cabecinha M, Vincent A, Halff EF, Kittler JT, Boucrot E & Partridge L (2017) “Myostatin-like proteins regulate synaptic function and neuronal morphology” Development 152975. LINK
2016
  • Logan A, Pell VR, Shaffer KJ, Evans C, Stanley NJ, Robb EL, Prime TA, Chouchani ET, Cochemé HM, Fearnley IM, Vidoni S, James AM, Porteous CM, Partridge L, Krieg T, Smith RAJ & Murphy MP (2016) “Assessing the mitochondrial membrane potential in cells and in vivo using targeted click chemistry and mass spectrometry” Cell Metab 23:379-385. LINK
2015
  • Speakman JR, Blount JD, Bronikowski AM, Buffenstein R, Isaksson C, Kirkwood TBL, Monaghan P, Ozanne SE, Beaulieu M, Briga M, Carr SK, Christensen LL, Cochemé HM, Cram DL, Dantzer B, Harper JM, Jurk D, King A, Noguera JC, Salin K, Sild E, Simons MJP, Smith S, Stier A, Tobler M, Vitikainen E, Peaker M & Selman C (2015) “Oxidative stress and life histories: unresolved issues and current needs”  Ecol Evol 5:5745-5757. LINK
  • Robb EL, Gawel JM, Aksentijević D, Cochemé HM, Stewart TS, Shchepinova MM, Qiang H, Prime TA, Bright TP, James AM, Shattock MJ, Senn HM, Hartley RC & Murphy MP (2015) “Selective superoxide generation within mitochondria by the targeted redox cycler MitoParaquat” Free Radic Biol Med 89:883-894. LINK
  • Jameson VJA, Cochemé HM, Logan A, Hanton LR, Smith RAJ & Murphy MP (2015) “Synthesis of triphenylphosphonium vitamin E derivatives as mitochondria-targeted antioxidants” Tetrahedron 71:8444-8453. LINK
  • Menger KE, James AM, Cochemé HM, Harbour ME, Chouchani ET, Ding S, Fearnley IM, Partridge L & Murphy MP (2015) “Fasting, but Not Aging, Dramatically Alters the Redox Status of Cysteine Residues on Proteins in Drosophila melanogaster” Cell Rep 11:1856-1865. LINK
  • Kinghorn KJ, Castillo-Quan JI, Bartolome F, Angelova PR, Li L, Pope S, Cochemé HM, Khan S, Asghari S, Bhatia KP, Hardy J, Abramov AY & Partridge L (2015) “Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction” Brain awv132. LINK
2014
  • Logan A, Cochemé HM, Pun PBL, Apostolova N, Smith RAJ, Larsen L, Larsen DS, James AM, Fearnley IM, Rogatti S, Prime TA, Finichiu PG, Dare A, Chouchani ET, Pell VR, Methner C, Quin C, McQuaker SJ, Krieg T, Hartley RC & Murphy MP (2014) “Using exomarkers to assess mitochondrial reactive species in vivo” Biochim Biophys Acta 1840:923-930. LINK
2013
  • Chouchani ET, Methner C, Nadtochiy SM, Logan A, Pell VR, Ding S, James AM, Cochemé HM, Reinhold J, Lilley KS, Partridge L, Fearnley IM, Robinson AJ, Hartley RC, Smith RAJ, Krieg T, Brookes PS & Murphy MP (2013) “Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I”, Nat Medicine 19:753-759. LINK
  • Cabreiro F, Au C, Leung K-Y, Vergara-Irigaray N, Cochemé HM, Noori T, Weinkove D, Schuster E, Greene NDE & Gems D (2013) “Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism” Cell 153:228-239. LINK
2012
  • Cochemé HM, Logan A, Prime TA, Abakumova I, Quin C., McQuaker SJ, Patel JV, Fearnley IM, James AM, Porteous CM, Smith RAJ, Hartley RC, Partridge L & Murphy MP (2012) “Using the mitochondria-targeted ratiometric mass spectrometry probe MitoB to measure H2O2 within living Drosophila” Nat Protoc 7:946-958. LINK
  • Collins Y, Chouchani ET, James AM, Menger KE, Cochemé HM & Murphy MP (2012) “Mitochondrial redox signalling at a glance” J Cell Sci 15:801-806. LINK
  • Smith RAJ, Hartley RC, Cochemé HM & Murphy MP (2012) “Mitochondrial Pharmacology” Trends Pharm Sci 33(6):341-352. LINK
  • Kelso G, Maroz A, Cochemé HM, Logan A, Prime T, Peskin A, Winterbourn C, James AM, Ross MF, Brooker S, Porteous C, Anderson R, Murphy MP & Smith RAJ (2012) “A mitochondria-targeted macrocyclic Mn(II) superoxide dismutase mimetic” Chem Biol 19:1237-1246. LINK
2011
  • Cochemé HM, Quin C, McQuaker SJ, Cabreiro F, Logan A, Prime TA, Abakumova I, Patel JV, Fearnley IM, James AM, Porteous CM, Smith RAJ, Saeed S, Carré JE, Singer M, Gems D, Hartley RC, Partridge L & Murphy MP (2011) “Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix” Cell Metab 13:340-350. LINK
  • Alic N, Andrews TD, Giannakou ME, Papatheodorou I, Slack C, Hoddinott MP, Cochemé HM, Schuster EF, Thornton JM & Partridge L (2011) “Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signaling” Mol Sys Biol 7:502. LINK
2003-2010
  • Cochemé HM & Murphy MP (2010) “Can antioxidants be effective therapeutics?” Curr Opin Investig Drugs 11:426-431. LINK
  • James AM, Cochemé HM, Murai M, Miyoshi H & Murphy MP (2010) “Complementation of coenzyme Q-deficient yeast by coenzyme Q analogues requires the isoprenoid side chain” FEBS J 277:2067-2082. LINK
  • Rodriguez-Cuenca S, Cochemé HM, Logan A, Abakumova I, Prime TA, Rose C, Vidal-Puig A, Smith AC, Rubinsztein DC, Fearnley IM, Jones BA, Pope S, Heales SJ, Lam BY, Neogi SG, McFarlane I, James AM, Smith RA, Murphy MP (2010) “Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice” Free Radic Biol Med 48:161-172. LINK
  • Cochemé HM & Murphy MP (2009) “Mitochondria as a source of reactive oxygen species” Biochem J doi:10.1042/BJ20090056.
  • Graham D, Huynh NN, Hamilton CA, Beattie E, Smith RA, Cochemé HM, Murphy MP & Dominiczak AF (2009) “Mitochondria-targeted antioxidant MitoQ10 improves endothelial function and attenuates cardiac hypertrophy” Hypertension 54:322-328. LINK
  • Cochemé HM & Murphy MP (2009) “Chapter 22: The uptake and interactions of the redox cycler paraquat with mitochondria” Methods Enzymol 456:395-417. LINK
  • Cochemé HM & Murphy MP (2008) “Complex I is the major site of mitochondrial superoxide production by paraquat” J Biol Chem 283:1786-1798. LINK
  • Smith RA, Adlam VJ, Blaikie FH, Manas AR, Porteous CM, James AM, Ross MF, Logan A, Cochemé HM, Trnka J, Prime TA, Abakumova I, Jones BA, Filipovska A & Murphy MP (2008) “Mitochondria-targeted antioxidants in the treatment of disease” Ann N Y Acad Sci 1147:105-111. LINK
  • Cochemé HM, Kelso GF, James AM, Ross MF, Trnka J, Mahendiran T, Asin-Cayuela J, Blaikie FH, Manas ARB, Porteous CM, Adlam VJ, Smith RAJ & Murphy MP (2007) “Mitochondrial targeting of quinones: therapeutic implications” Mitochondrion 7:S94-102. LINK
  • James AM, Cochemé HM, Murphy MP (2005) “Mitochondria-targeted redox probes as tools in the study of oxidative damage and ageing” Mech Ageing Dev 126:982-986. LINK
  • Ross MF, Kelso GF, Blaikie FH, James AM, Cochemé HM, Filipovska A, Da Ros T, Hurd TR, Smith RA & Murphy MP (2005) “Lipophilic triphenylphosphonium cations as tools in mitochondrial bioenergetics and free radical biology” Biochemistry (Moscow) 70:222-230. LINK
  • James AM, Cochemé HM, Smith RA & Murphy MP (2005) “Interactions of mitochondria-targeted and untargeted ubiquinones with the mitochondrial respiratory chain and reactive oxygen species” J Biol Chem 280:21295-21312. LINK
  • Smith RA, Kelso GF, Blaikie FH, Porteous CM, Ledgerwood EC, Hughes G, James AM, Ross MF, Asin-Cayuela J, Cochemé HM, Filipovska A & Murphy MP (2003) “Using mitochondria-targeted molecules to study mitochondrial radical production and its consequences” Biochem Soc Trans 31:1295-1299. LINK
  • Murphy MP, Echtay KS, Blaikie FH, Asin-Cayuela J, Cochemé HM, Green K, Buckingham JA, Taylor ER, Hurrell F, Hughes G, Miwa S, Cooper CE, Svistunenko DA, Smith RA & Brand MD (2003) “Superoxide activates uncoupling proteins by generating carbon-centered radicals and initiating lipid peroxidation” J Biol Chem 278:48534-48545. LINK